It's the easternmost accessible city in the official game area upon release, and remains so even after the Scandinavia DLC was released.
The city is quite compact to truckers, with almost all facilities centered at a crossroad.
ITCC and Transinet are the two companies having factory / depot in the city. eAcres and TREE-ET have depots to the west and southeast of the city respectively, with TREE-ET mill being the easternmost location a trucker can access without mods.
Just like most Polish cities to the east of the country's capital, Warszawa, no highway or expressway directly serves Bialystok, although the road between Bialystok and Warszawa is designated as Droga krajowa nr 8 (National Road 8).
The road exiting Bialystok to the north is also part of Road 8 in real-life, but no in-game sign suggests this. In the game, it turns west at an unnamed town and eventually reaches Olsztyn.
Another minor road runs south of Bialystok towards Lublin.