Just like most Czech highways, the D8 starts from Praha, the country's capital. It then takes a northerly route across the Bohemian mountains, eventually reaching the Czech-German border, where the German Bundesautobahn 17 takes over. The nearest German city along the route is Dresden.
- The tunnel encountered on the D8 is Tunel Panenská, the longest road tunnel in Czech Republic.
- The "Cat Eyes" footbridge over the D8 is also rendered in ETS 2.
- The game renders the D8 as a continuous highway. In real-life the Dálnice is yet to be completed.