Duisburg is the northernmost of the triplet in-game cities in northwestern Germany, the other two being Düsseldorf and Köln. Possibly due to this, only two companies have depots in Duisburg, namely LKW and NBFC.
All accesses to Duisburg are minor or unnumbered roads.
The main road through Duisburg exits the city to the southeast and heads for Bundesautobahn 45 near Dortmund. Two minor roads branches from it: One runs south to Düsseldorf and Köln, while the other goes northeast towards Bundesautobahn 1 near Osnabrück.
A link road running northeast from Duisburg also terminates on the road towards Osnabrück. Further along the way, another minor road branches west and runs across three national borders (Germany – Netherlands – Belgium – France) before ending near Calais.